Chemical Stability of Bortezomib Solutions in Original Manufacturer Vials
نویسندگان
چکیده
Bortezomib is recommended for the treatment of patients with multiple myeloma. Clinical investigations have been completed or are under way to evaluate the safety and efficacy of bortezomib alone or in combination with chemotherapy in multiple myeloma, both at relapse and presentation, as well as in other cancer types. Bortezomib binds to the proteasome and does so "reversibly" (this is a chemical term that means that the bortezomib molecule can come free under different micro-cellular chemical conditions.) Normal healthy (non-cancer) cells are not as prone to damage from this binding after the Bortezomib comes off, as cancer cells are. Malignant cells suffer a breakdown even after inhibition of the proteasome for a short time. The objective of this work was to evaluate the stability of bortezomib reconstituted with sterile NaCl 0.9% to a concentration of 2.5 mg mL in original manufacturer vial refrigerated at 4 C in the dark.
منابع مشابه
Stability of unused reconstituted bortezomib in original manufacturer vials.
UNLABELLED BACKGROUND. Bortezomib is a modified dipeptidyl boronic acid analogue used to treat multiple myeloma, mantle cell lymphoma, and, more recently, renal transplantation graft rejection. As per manufacturer recommendations, bortezomib is to be administered within 8 h of preparation or may be stored for up to 8 h in the vial or a syringe following reconstitution. Preserving unused reconst...
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Bortezomib is a drug used in the treatment of myeloma multiple. The experiments carried out demonstrate that bortezomib is cytotoxic for different types of neoplastic cells and reduces the tumor-like growth “in vivo” in many preclinical models of tumor, including myeloma multiple. In a recent study, was evaluated the effectiveness and security of the subcutaneous administration of bortezomib as...
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